Physical Activity, Sedentary Behavior and Cardiorespiratory Fitness Associations with Short-Term Heart Rate Variability and Inflammatory and Oxidative Stress Markers

DEL ROSSO, SEBASTIAN; BARAQUET, LUCÍA; BERGERO, GASTÓN; MAZZOCCO, YANINA; AOKI, PILAR M; PEROVIC, NILDA R.

Congreso; European College of Sports Sciences Congress; 2021

Objective: To assess the associations between objectively measured physical activity (PA), sedentary behavior (SB), and cardiorespiratory fitness (CRF) with indices of heart rate variability (HRV), and plasma inflammatory and oxidative stress markers.Methods: 44 participants [29 women, 15 men, age = 49.56.4 yrs, BMI = 28.16.2 kg·m-2] from the ?Lifestyles and Oxidative Stress Markers in Cardiometabolic Risk Study?. Data were collected between 7.00-10.00 A.M. in a fasted state and without prior consumption of coffee, tea, or tobacco; in the following order: Resting heart (HR) rate for HRV analysis (SDNN, RMSSD, LF, HF, LF/HF, SD1, SD2, Sample Entropy, PNS and SNS index), a blood sample to measure inflammatory [C-reactive protein (CRP) and cytokines (IL-1β, INF-γ, TNF, MCP-1, IL-6, IL-8, IL-10, IL-18, IL-23] and oxidative stress markers [Catalase (CAT) and Glutathione Peroxidase (GPX)], anthropometric measures, a submaximal cycling test for VO2max estimation with active recovery to assess absolute HR recovery (30s, 1, 2, 3, 4 and 5 min, and Δ30, Δ1, Δ2, Δ3, Δ4, Δ5) and HRR kinetics [time constant (τ), and amplitude (ΔHRR)] and 7-day PA monitoring [time sedentary, time in light PA (LPA) and time in moderate to vigorous PA (MVPA) all expressed in min·day-1]. Non-normal distributed variables log-transformed (ln) and all statistics were performed at α=0.05.Results: Women spent more time in SB (P=0.035, ES=0.72) whit less sedentary breaks (P=0.014, ES=0.43), higher ln IL-6 (P=0.02, ES=0.84) and ln TNF (P=0.01, ES=0.97) and lower HRV indices [SDNN, LF/HF, SD2 (P>0.05)] than men. There were no significant differences in PA or SB between groups defined by a determined CRF. However, the group with high CRF showed lower values of ln TNF (P=0.02) and IL-10 (P=0.003), a tendency for lower ln IL-1β and ln IL-6 (P=0.05) and higher HRV indices [RMSSD, PNS, SampEn, SD1 (P