WIRED CHOLESTEROL METABOLISM IS RELATED WITH FERROPTOSIS LEADING TO PARKINSONISM-LIKE DISORDERS

MANISCALCHI ATHINA; BENZI JUNCOS ORIANA N.; CONDE, MELISA A.; FERMENTO E.; FUNK, MELANIA I.; CURINO A.; FACCHINETTI N. P.; ALZA, NATALIA P.; SALVADOR, GABRIELA A.

Mar del Plata

Congreso; REUNIÓN CONJUNTA SAIC, SAI&FAIC, SAFIS 2022; 2022

SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA, SOCIEDAD ARGENTINA DE INMUNOLOGÍA, SOCIEDAD ARGENTINA DE FISIOLOGÍA

Ferroptosis is a novel type of oxidative and non-apoptotic cell death associated withneurodegenerative disorders. Previously, we have established an in vivomodel ofironoverload(C57BL/6mice treated with iron-sucrose)thattriggersferroptosisin the nervoussystemrelatedwithmarkers of neurodegeneration.Our aimwasto characterize lipidmetabolismalterationsinmice midbrain ofthis experimental model.We found thatmidbrain lipid contentwas alteredbyiron overload. Cholesterol and diacylglycerol levels were increased (p