Title: What is known about the effect of SARS-CoV-2 and vaccines on ovarian function?

HERRERO, YAMILA; VELAZQUEZ CANDELA; MAYRA BORDAQUIEVICH; MELANIE NEIRA; HAUK, VANESA; ZUÑIGA IGNACIO; MARTINEZ GUSTAVO; LAVOLPE, MARIANO; VEIGA, FLORENCIA; LEOPOLDINA SCOTTI; ABRAMOVICH, DALHIA; FERNANDA PARBORELL

Valdivia

Congreso; V Meeting Latin American Chapter Developmental Origins of Health and Disease (DOHaD) Society - XXXIV Meeting Chilean Society of Reproduction and Development; 2023

Chilean Society of Reproduction and Development Joint Meeting.

Background. We have previously shown that alterations in ovarian function can beobserved up to 9 months after SARS-CoV-2 infection. So far, no studies havedetermined the long-term effects of SARS-CoV-2 infection and the vaccine onfertility. We propose two objectives: a) To evaluate ovarian function in patients whohave suffered from COVID-19 (mild symptoms) up to 18 months post-infection andb) To assess the effect of vaccines against COVID-19 on reproductiveperformance.Methods. A total of 125 women (21–43 years old) under ART were recruitedbetween November 2020 and May 2022 from 4 reproductive medicine institutions.For objective a), the patients were classified into: control group (n=30) (no positivetest for COVID-19) and the post-COVID-19 group (n=55) (at least one positive testby PCR). For objective b), patients are classified into: the unvaccinated group(n=70) and the group vaccinated for COVID-19 (n=55).Results. The results showed that in patients (without vaccination) the number ofretrieved and mature oocytes decreased up to 12 months after COVID-19 infectioncompared to the control (p