INVESTIGADORES
DATTILO Melina Andrea
congresos y reuniones científicas
Título:
Role of estrogen-related receptor alpha and estrogen receptor alpha on transcriptional regulation of Acyl-CoA synthetase 4 in breast cancer cells
Autor/es:
DATTILO, MELINA A.; BENZO, YANINA; LOPEZ PAULA; HERRERA, LUCÍA M.; PRADA, JESICA G.; ORLANDO, ULISES D.; CASTILLO ANA FERNANDA; MALOBERTI, PAULA M.
Reunión:
Congreso; LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2019
Resumen:
Acyl-CoA synthetase 4 (ACSL4) overexpression plays a causal role in the aggressiveness of triple negative breast cancer (TNBC). In turn, a negative correlation has been established between ACSL4 and estrogen receptor alpha (ERα) expression. Our hypothesisis that transcriptional regulation is involved in the differential expression of ACSL4 in breast cancer cells. We observed that TNBC cells(MDA-MB-231 and Hs578T) exhibit greater activity of ACSL4 promoter than ERα+ cell lines(MCF-7 and T47D) (p
