EXPERIMENTAL STUDY OF BIOCHEMICAL AND STRUCTURAL EFFECTS OF METHYLPHENIDATE IN RENAL AND CARDIAC TISSUE IN RATS

TAPIA PABLO; FELDMAN, G.; GRANGER, S; BORELLI, VALERIA; ORTÍZ MAYOR, M.; MARTINEZ RIERA, NORA

BIOCELL

INST HISTOL EMBRIOL-CONICET

Lugar: San Miguel de Tucumán; Año: 2021 vol. 45 p. 44 - 44

0327-9545

For treatment of attention deficit and hyperactivity, one of the psychostimulant drugs used is methylphenidate, pharmacologically similar to cocaine and amphetamine. There is insufficient evidence in long-term treated patients with this drug, in terms of modifications in biochemical and anatomopathological parameters. Objectives: To evaluate in experimental animals, biochemical and structural modifications in renal and cardiac parenchyma produced by methylphenidate. Materials and methods: adult white Wistar rats 4 groups (N = 2): (1) with ad-libitum water, (2) treated with methylphenidate, 20?30 mg/day (therapeutic) one month, (3) treatment group 2 2 months. (4) same treatment group 2, 3 months. Total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides and creatinine were determined. Renal and cardiac parenchymas were evaluated by optical microscopy with hematoxylin-eosin. Results: Group 2, no biochemical modifications or anatomophysiological alterations were found. In groups 3 and 4, significant differences were found in terms of total cholesterol, HDL cholesterol, LDL cholesterol and creatinine. There are no significant differences in triglycerides. All groups with methylphenidate showed weight gain vs. control group. Pathological anatomy: in groups 3 and 4, macroscopically weight gain was observed in the two organs studied. Microscopically: at the heart level they had bleeding in the right cavity and right atrial enlargement. At renal level, both showed macro glomeruli with slight increase in cellularity. Tubules exhibited intraluminal cell flaking with focal nuclear loss linking to tubular necrosis changes. Congestion was observed in the interstitium and vessels and only in group the presence of papillary proliferation and angioectasia was found. Conclusion: This study coincides with the literature on the need to expand research related to dosage, time and pathologies associated with the use of methylphenidate.