Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta-analysis

SALAS-HUETOS A; MAGHSOUMI-NOROUZABAD L; JAMES ER; CARELL DT; ASTON KI; JENKINS TG; BECERRA-TOMÁS N; JAVID AZ; AIRES V ; TORRES PJ; LUQUE EM; RAMÍREZ ND; MARTINI AC (DEBE SER CONSIDERADA ÚLTIMO AUTOR CONJUNTO); SALAS-SALVADÓ J

OBESITY REVIEWS

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2021 vol. 22 p. 13082 - 13082

1467-7881

Infertility is defined as inability to have a child after at least one year of regular unprotected sexual intercourse. Nearly half causes of infertility areattributed to male partner. There is increasing evidence denoting the key role of nutrition and male obesity on sperm quality and male fertility. The present updated systematic review and meta-analysis aimed to summarize the evidence from high-quality published studies investigating the potential associationsof adiposityandsperm quality and reproductive hormones. We conducteda systematic search of the literature published in MEDLINE-PubMed and EMBASE databasesand a hand searching of reference list until June 2019, in accordance with the guidelines of the PRISMA. Based on the criteria in our review, 154 eligible publications (+14 after complementary searching, and +1 recently published data obtained from contacting the corresponding authors of all the studies included) were used for data abstraction.Finally, 60 articles were included in the qualitative analysis and 28 in thequantitative analysis. Our systematic review results indicated that unhealthy weight (based in WHO) was associated with low semen quality parameters (i.e. semen volume, sperm count and concentration, sperm vitality and normal morphology) and some specific reproductive hormones (e.g. inhibin B, total testosterone, and sex hormone?binding globulin). Unhealthy weight was also positively associated with high prolactine, and estradiol concentrations. Meta-analysis of existing data indicated that overweight and/or obesity was associated with lower sperm quality (i.e. semen volume, sperm count and concentration, sperm vitality, total motility and normal morphology),and underweight was also associated to low sperm normal morphology.In conclusion, or results suggest that maintaining a healthy body weight is important for increasing sperm quality parameters and maybe male fertility. This may be taken into account in case of assisted reproduction and live-birth rate.