THE ROLE OF INTRAGESTATIONAL GHRELIN ON POSTNATAL DEVELOPMENT AND REPRODCUTIVE PROGRAMMING IN MICE.

TORRES PJ; LUQUE EM; PONZIO MF; CANTARELLI V; DIEZ M; FIGUEROA SI; VINCENTI LM; CARLINI VP; MARTINI AC

REPRODUCTION

BIOSCIENTIFICA LTD

Lugar: Bristol; Año: 2018 vol. 156 p. 331 - 341

1470-1626

The purpose of this study was to evaluate the intragestational role of ghrelin in offspring development and reproductive programming in a mouse model of ghrelin imbalance during pregnancy. Female mice were injected with ghrelin (supraphysiological levels; 4 nmol/animal/day), antagonist (endogenous ghrelin inhibition with (D-Lys3)GHRP-6, 6 nmol/animal/day) or vehicle (control=normal ghrelin levels) for the entire pregnancy. Parameters evaluated in litters were growth, physical, neurobiological and sexual development and, at adulthood, reproductive function. Litter size and initial weight did not vary between treatments. Male pups from dams treated with ghrelin showed higher body weight increase until adulthood (31.7±0.8 vs control=29.7±0.7, n=11-14 litters/treatment; p