INVESTIGADORES
FRIES Alexander Erich
artículos
Título:
Structural and biochemical basis for the firm chemo- and regioselectivity of the nitro-forming N-oxygenase AurF
Autor/es:
ALEXANDER FRIES; ROBERT WINKLER; CHRISTIAN HERTWECK
Revista:
CHEMICAL COMMUNICATIONS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: CAMBRIDGE; Año: 2010 vol. 46 p. 7760 - 7762
ISSN:
1359-7345
Resumen:
Site-directed mutagenesis based on the crystal structure of AurF, a nitro group forming monooxygenase from Streptomyces thioluteus, revealed that AurF variants are capable of selectively transforming guanidyl- and amidinyl-substituted anilines into the corresponding nitro compounds. Our results provide new insights into the biochemical basis of regioselective N-oxygenation.
