1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans

MARC PYBUS; PIERRE LUISI; JOHANNES ENGELKEN; GIOVANNI M. DALL'OLIO; MANU UZKUDUN; HAFID LAAYOUNI; JAUME BERTRANPETIT

Barcelona

Encuentro; 4th meeting of Spanish Society for Evolutionary Biology; 2013

Searching for Darwinian selection in natural popula-tions has been the focus of a multitude of studiesover the last decades. Here we present the 1000Genomes Selection Browser 1.0 (http://hsb.upf.edu)as a resource for signatures of recent natural selec-tion in modern humans. We have implemented andapplied a large number of neutrality tests as well assummary statistics informative for the action of se-lection such as Tajima?s D, CLR, Fay and Wu?s H, Fuand Li?s F* and D*, XPEHH, "iHH, iHS, FST, "DAF andXPCLR among others to low coverage sequencingdata from the 1000 genomes project (Phase 1;release April 2012). We have implemented a publiclyavailable genome-wide browser to communicate theresults from three different populations of WestAfrican, Northern European and East Asian ancestry(YRI, CEU, CHB). Information is provided in UCSC-style format to facilitate the integration with the richUCSC browser tracks and an access page is providedwith instructions and for convenient visualization. Webelieve that this expandable resource will facilitatethe interpretation of signals of selection on differenttemporal, geographical and genomic scales.