BECAS
SANCHIS Ivan
congresos y reuniones científicas
Título:
Cholinesterases natural inhibitors with antioxidant potential isolated from frog skins (Anura: Hylidae): Application in Alzheimer´s disease
Autor/es:
SPINELLI, ROQUE; SANCHIS, IVÁN; TONARELLI, GEORGINA; SIANO, ALVARO
Lugar:
Buenos Aires
Reunión:
Simposio; Buenos Aires AAIC Satellite Symposium; 2018
Institución organizadora:
Alzheimer's Association
Resumen:
The skin of anuran amphibians is a hugesource of bioactive compounds, among which are peptides. Their isolation,identification, and characterization have led to the development of therapeuticagents with several applications in human health. In Alzheimer´s disease (AD)the inhibition of Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE)represent the only symptomatic treatment. AChE also plays an important role inthe formation of β-amyloid peptide (Aβ) deposits, increasing the cerebraldamage in the AD. On the other hand, Aβ aggregates lead the production ofreactive oxygen species, oxidative stress, and cell death. Thus, the use ofantioxidant agents could be useful to delaying or preventing this disorder
