BECAS
SANCHIS Ivan
artículos
Título:
Natural multi-target modulators of pathological pathways in Alzheimer's disease isolated from the Rhinella arenarum skin
Autor/es:
SPINELLI, ROQUE; ÁLVARO, RIETMANN; IVAN, SANCHIS; SIANO, ALVARO
Revista:
NATURAL PRODUCT RESEARCH
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: Londres; Año: 2021
ISSN:
1478-6419
Resumen:
The skin of anuran amphibians is a rich source of compounds with great medicinal potential. Alzheimer´s disease (AD) is a complex disease associated with numerous pathological pathways, making their simultaneous modulation necessary. Nowadays the development of anti-AD drugs is focused on a Multi-Target Directed Ligands strategy. Herein we report the bioactivity of the skin extracts of the toad Rhinella arenarum obtained by an invasive and non-invasive methods, against five AD pathological targets (AChE, BChE, MAO-B, antioxidant and chelating activities). The extract derived from the non-invasive technique showed the highest biological activity, being capable of acting on all or almost all the pathological targets of AD, while also avoiding harm to the animal.
