Orcokinin neuropeptides inhibit courtship and are involved in the regulation of other innate behaviors in the fruit fly Drosophila melanogaster

VOLONTÉ, MARIANO; SILVA MOELLER, VALERIA; PALACIOS MUÑOZ, ANGELINA; FRENKEL, LÍA; EWER, JOHN; ONS, SHEILA

Congreso; XXXV Annual Meeting of the Argentinian Society for Neuroscience; 2020

Sociedad Argentina de Neurociencias

In animals, neuropeptidergic signaling is essential for the regulation of survival and reproduction. In insects, Orcokinins are poorly studied, despite their high level of conservation among different orders. In particular, there are currently no reports on the role of Orcokinins in the experimental insect model, the fruit fly, Drosophila melanogaster. In the present work, we made use of the genetic tools available in this species to investigate the role of Orcokinins in the regulation of different innate behaviors including ecdysis, sleep, locomotor activity, oviposition, and courtship. We found that RNAi-mediated knockdown of the orcokinin gene caused a disinhibition of male courtship behavior, including the occurrence of male to male courtship, which is rarely seen in wildtype flies. In addition, orcokinin gene silencing caused a reduction in egg production. Orcokinin is emerging as an important neuropeptide family in the regulation of the physiology of insects from different orders. In the case of the fruit fly, our results suggest an important role in reproductive success.