Synthesis of porphyrin-polyethylenimine conjugates as antimicrobial agents

BOARINI, MILENA B.; PÉREZ, M. EUGENIA; NATALIA GSPONER; MILANESIO, MARIA ELISA

Conferencia; The 25th International Electronic Conference on Synthetic Organic Chemistry; 2021

5,15-di(4-(N,N-dimethylaminophenyl)-10,20-di(pentafluorophenyl)porphyrin (1) and 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (2) were synthesized in 24% and 36%, respectively. An aromatic nucleophilic substitution reaction was used to obtain conjugated polymers based in these porphyrins covalently linked to polyethylenimine (PEI-1 and PEI-2). Spectroscopic and pho-todynamic properties indicate that these polymers are potential phototherapeutic agents for the eradication of bacteria.