Effects of PUFAs in a Mouse Model of HSV-1 Chorioretinitis

ALEJANDRO BERRA; JULIA TAU; GUSTAVO ZAPATA; PABLO CHIARADIA

OCULAR IMMUNOLOGY AND INFLAMMATION

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2016

0927-3948

AbstractPurpose: to examine the effects of n-3 and n-6 polyunsaturated fatty acids (n-3 and n-6 PUFAs) in a murine model of herpetic chorioretinitis.Methods: BALB/c mice were fed on three high fat diets which contained: Menhaden oil (rich in n-3 PUFAs), Safflower oil (rich in n-6 PUFAs) or Corn oil (rich in saturated fatty acids) as control group, 14 days previously and 12 days following anterior chamber (AC) HSV-1 inoculation.Results and Conclusion: Mice fed on Menhaden oil present an early development of contralateral chorioretinitis by day 6 post AC HSV-1 inoculation and also significant increase of RNA HSV-1 expression compared with Safflower and Corn oil groups. Furthermore, mice fed on Menhaden oil showed a significant decrease secretion of TNF-α, IFN-γ, IL-2 and IL-10 in splenic cells and both retinas.