Trypanosoma cruzi infection alters adipocyte homeostasis affecting the expression of metabolic enzymes, PPARs and adipokines promoting an ninflammatory phenotype

GONZALEZ FLORENCIA BELEN; PACINI MARIA FLORENCIA; VILLAR SILVINA RAQUEL; D'ATTILIO LUCIANO; BOTTASSO OSCAR ADELMO; PIWIEN PILIPUK GRACIELA; PÉREZ ANA ROSA; CECILIA FARRÉ

Mar del Plata

Congreso; SAI.SACI.SAFIS 2018; 2018

Sociedad Argentina de Inmunologia

Adipose tissue (AT) is a target of T. cruzi (Tc) infection, being a parasitereservoir in mice and humans. Previously, we reported that acutemurine Tc infection is linked to a severe AT loss, probably triggeredby inflammation, as well as by the parasite itself. Here, we evaluatedhow infection affects AT homeostasis, considering adipocyte anabolic/catabolic pathways and immune-endocrine patterns in C57BL/6mice (n= 5-6/group) . During infection, both catabolic and anabolicpathways are profoundly affected, since mRNA expression of lipolytic(HSL and ATGL) and lipogenic (LPL, FAS and DGAT) enzymesmeasured by qPCR was intensely downregulated (all enzymes, Covs Tc p