THYMIC EXPORTATION AND EFFECTOR FUNCTION OF MEMORY-LIKE CD8+ T CELLS

MARÍA ESTEFANÍA VIANO; ELIANA BAIGORRÍ; CINTHIA STEMPIN; ANA ROSA PEREZ; BRENDA DINATALE; FLORENCIA PACINI; CAMILA BULFONI; FLORENCIA GONZALEZ; NICOLAS L. LIDÓN; FABIO CERBAN; MARÍA CECILIA RODRÍGUEZ GALÁN

Mar del Plata

Congreso; LXX REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA (SAI) & 3ER CONGRESO FRANCO-ARGENTINO DE INMUNOLOGÍA (FAIC); 2022

Sociedad Argentina de Inmunologia

Memory-like cells are a subset of CD8+ T cells that present a memory phenotype without previous antigen encounter. They are a heterogeneous group of cells compose of innate CD8+ T cells that arisein the thymus (TIM) and are exported to secondary lymphoid organs(SLO) or, could develop directly in SLO where are named as virtualCD8+ T cells (TVM). TVM/TIM rapidly respond to IL-12 and IL-18 andplay a protective role during the early phase of bacteria, viral andparasite infections. We have previously reported that thymi from Trypanosoma cruzi (Tc)-infected mice are highly enriched on TIM. TVM/TIM can be distinguished from conventional memory T cells (TMEM)by their low expression of CD49d. While residing in the thymus,phenotypic analysis in OT-I mice demonstrate that OVA tetramer+(OVAt+) single positive CD8 (SP8) cells (not specific for the parasite)expressed higher levels of CD44, CD122, CD5, CD69, Qa2 and decreased levels of CD24 compared to conventional polyclonal SP8cells (p