PHARMACOLOGICAL INTERACTIONS OF MONOTERPENES AND IN VIVO EVALUATION OF THEIR NEMATODICIDAL ACTIVITY

VICTORIA MIRÓ; LIVIO COSTA JUNIOR; LUIS ALVAREZ; CARLOS LANUSSE; GUILLERMO VIRKEL; ADRIAN LIFSCHITZ

Brasil

Congreso; RedIF 2021 - Show Case em Farmacometria; 2021

The search for alternatives to control gastrointestinal nematodes in ruminants is relevant considering the increasing of anthelmintic resistance. The use of monoterpenes may contribute for improving parasite control. This work evaluated in vitro the effects of monoterpenes on the processes of drug metabolism and intestinal accumulation and, additionally, the anthelmintic activity of the best ?candidate?. The intestinal accumulation of Rhodamine-123 (Rho123), P-glycoprotein substrate, was studied in cattle ileum in the presence or absence of carvone (CNE), geraniol (GNL) and citral (CTL). The effect of CNE, GNL and CTL on flavin-containing monooxygenase (FMO) and cytochrome P450 (CYP) dependent metabolism was assessed in sheep liver microsomes. The presence of CNE and GNL increased the accumulation of Rho123 by 66 % and 46 % respectively (P