Chronic treatment with Zn-Telmisartan improves cardiac function and the protective renin-angiotensin-system axis in ovariectomized spontaneously hypertensive rats

MARTINEZ, VALERIA ROMINA; DIAZ, ROMINA GISEL; PEREZ, NESTOR GUSTAVO; VELEZ RUEDA, JORGE OMAR; LOFEUDO, JUAN MANUEL; SILVA, MAURO; GIRONACCI, MARIELA; WILLIAMS, PATRICIA ANA MARÍA; DE GIUSTI, VERÓNICA

Buenos Aires

Congreso; Reunión Anual de la Sociedad Argentina de Fisiología; 2021

Sociedad Argentina de Fisiología

During menopause exits an imbalance between the pressor Angiotensin II (Ang II) and the protective (Ang 1-7) arms of the renin-angiotensin-system (RAS), which leads to oxidative stress, hypertension and cardiac dysfunction. Restoring RAS balance would prevent cardiovascular diseases in menopausal women. We have previously modified the structure of telmisartan (Telm), an Ang II receptor blocker, with Zinc (ZnTelm), demonstrating a higher drug effectiveness. In this work, we examined if chronic treatment with ZnTelm, in comparison with Telm alone, was a better alternative to prevent cardiovascular damage during menopause. We used 16-week-old spontaneously hypertensive rats (SHR) which were sham-operated or bilateral ovariectomized (OVX-SHR). OVX-SHR rats were randomly divided in 3 groups: no-treated (control), treated with Telm or treated with ZnTelm (10 or 11 mg/kg/day drinking water for 8 weeks). Results (n=6 per group) were analyzed by ANOVA. * p