AZILSARTAN AND ITS Zn(II) COMPLEX. SYNTHESIS, ANTICANCER MECHANISMS OF ACTION AND INTERACTION WITH BOVINE SERUM ALBUMIN

MARTINEZ, VALERIA ROMINA; TODARO, JUAN SANTIAGO; AGUIRRE, MARIA VICTORIA; PIRO, OSCAR; ECHEVERRÍA, GUSTAVO; FERRER, EVELINA GLORIA; WILLIAMS, PATRICIA A. M.

Buenos Aires

Congreso; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS; 2017

SOCIEDAD ARGENTINA DE FARMACOLOGÍA EXPERIMENTAL

Azilsartan is the eighth approved member of angiotensin II receptorblockers for hypertension treatment. Considering that some drugshave additional beneficial effects on health when administered, westudied its effects and mechanisms of action on a human lung cancercell line A549. We have also modified the structure of the drugby complexation with Zn(II) cation and determined the anticancereffect. The crystal structure of the new binuclear Zn(II) complex,for short [Zn2(azil)2(H2O)4].2H2O (ZnAzil), was determined by X-raydiffraction methods. A549 and MRC-5 cell lines were used for theanticancer determinations. The results of the MTT assay showedthat the complex behaved as good antiproliferative agent (IC50 = 155μM ± 12, p