AZILSARTAN AND ITS Zn(II) COMPLEX. SYNTHESIS, ANTICANCER MECHANISMS OF ACTION AND INTERACTION WITH BOVINE SERUM ALBUMIN

MARTINEZ, VALERIA; TODARO, JUAN S.; AGUIRRE, MARÍA V.; ECHEVERRÍA, GUSTAVO A.; PIRO, OSCAR E.; FERRER, EVELINA G.; WILLIAMS, PATRICIA A.M.

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Abstract: Azilsartan is the eighth approved member of angiotensin II receptor blockers for hypertension treatment. Considering that some drugs have additional beneficial effects on health when administered, we studied its effects and mechanisms of action on a human lung cancer cell line A549. We have also modified the structure of the drug by complexation with Zn(II) cation and determined the anticancer effect. The crystal structure of the new binuclear Zn(II) complex, for short [Zn2(azil)2(H2O)4].2H2O (ZnAzil), was determined by X-ray diffraction methods. A549 and MRC-5 cell lines were used for the anticancer determinations. The results of the MTT assay showed that the complex behaved as good antiproliferative agent (IC50 = 155 µM ± 12, p