Candesartan, Losartan and Valsartan Zn(II) complexes. Bovine serum albumin interactions

MARTINEZ, VALERIA ROMINA; FERRER, EVELINA GLORIA; WILLIAMS, PATRICIA ANA MARÍA

Future Medicinal Chemistry

Future Science

Lugar: Londres; Año: 2021

1756-8919

Background: the pharmacological response and the therapeutic efficacy of a drug depends on the interactions with plasma proteins. Methodology: The interaction of BSA with metal complexes of antihypertensive drugs, Zn(II)/sartan complexes (candesartan, valsartan, losartan) was investigated using fluorescence quenching determinations at different temperatures. Results: The binding studies of the compounds with bovine serum albumin (BSA) showed a static quenching and moderate binding with calculated constants in the range of 104 - 106 M-1, indicating potent serum distribution via albumins. In all cases, negative values of free energy are indicative of spontaneous processes and the complexes BSA/compound resulted stabilized through hydrogen bonding and van der Waals forces. The results for the sartans agree with reported pharmacokinetics studies. Conclusion: It has been determined that the three sartans and the Zn complexes could be transported and distributed by albumin.