Canonical phospholipase D isoforms in visual function and ocular response to stress

BERMÚDEZ, VICENTE (PRIMERA AUTORIA COMPARTIDA); TENCONI, PE (PRIMERA AUTORIA COMPARTIDA); GIUSTO, NORMA M.; MATEOS, MELINA V. (CORRESPONDING AUTHOR)

EXPERIMENTAL EYE RESEARCH

ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2022

0014-4835

Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) togenerate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Through thegeneration of these lipid messengers, the PLD pathway can modulate several cellular events, such as proliferation, membrane trafficking, autophagy and the inflammatory response, among many others. This review summarizes the participation of canonical PLD isoforms in physiological and pathological responses in the eye.Although the role of the PLD pathway in ocular and retinal response to stress has not been fully elucidated,pharmacological inhibition of these signaling enzymes seems to be a promising therapeutic tool to avoid in inflammatory processes in the retina, abnormal cellular proliferation on the ocular surface and pathologicalneovascularization. On the contrary, the modulation of classical PLDs may potentiate corneal healing. In summary, the knowledge of the role of PLD1 and PLD2 in the molecular basis of ocular inflammatory and degenerative diseases opens new avenues for potential therapeutic exploration