Tryptophan-derived metabolite, indole-3-propionic acid, promotes homeostasis and prevents inflammation of the intestinal mucosa

ROMAGNOLI, PABLO A.; SHENK GK; SHORE BS; PHAM QM; MAHER, L; KHANNA KM

Santiago de Chile

Simposio; OralGut Symposium ?Mucosal immunity at the Oral-Gut axis in health or disease?; 2020

Fundación Ciencia & Vida

Microbiota-derived metabolites serve as signals that can promote the homeostasis of the epithelial cell layer of the intestinal mucosa. These signals can shape immune responses to bacterial pathogens as well as to prevent dysregulated responses to microbiota that result in inflammatory bowel disease (IBD). We tested the hypothesis that the metabolite indole-3-propionic acid (IPA), generated by commensal bacteria following the tryptophan metabolism, provides the signals that promote intestinal mucosa homeostasis and in turn control inflammation to prevent IBD. The effect of IPA in the intestinal mucosa was investigated using a mouse model of colitis caused by oral infection with Citrobacter rodentium. Remarkably, we found that IPA treatment prevents colitis in mice (p