EPIGENETIC LATERALITY DIFFERENCES IN BREAST CANCER

SOFIA MASUELLI; EMANUEL CAMPOY; SEBASTIAN REAL; MARCESE DIEGO; MARIA ROQUE MORENO

Mar del Plata

Congreso; Reunión anual de la Sociedad Argentina de Investigación Clínica; 2019

Sociadad Argentina de Investigación Clinica

Breast Cancer is a heterogeneous disease.By previous studies we determined that mammary tumors of left-right sides (L-R) differ in their behavior as inferred from theirmethylation profiles. Normal breast L-R tissues have not identical environments; they differ in size, irrigation and fat composition. It is also known that epigenetics functions as a bridge between environment and gene expression. Our hypothesis sustains that L-R tumors differ in epigenetically regulated pathways, provoked by the diverse L-R microenvironment. To study this, we performed in-silico and in-vivo analyses. From database cBioPortal Provisional Breast Cancer, 708 tumors with information for 16.000 genes were included and L-R methylation medias were compared for each gene. The top 169 genes with significant L-R difference above 3% were selected (T test, p