Alpha6-beta4- Integrin Genetic Variations (A380T and R1281W) and Breast Cancer Risk in an Argentinian Population

ACOSTA, KARINA BEATRIZ; LORENZINI CAMPOS, MN; ETCHEVERRY, SUSANA; ZAPATA, PEDRO DARÍO

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI

Lugar: Basel; Año: 2016 vol. 17 p. 1 - 8

1422-0067

The 64 integrin is composed of the 6 and 4 subunits that are encoded by the ITGa6 and the ITGb4 genes, respectively. The 64 main function is to intervene in lamination and epithelia integrity maintenance by cell-matrix interactions. This integrin appears to have importance in breast cancer malignancy, as well as other epithelial carcinomas. The aim of this work was to investigate thepotential role of ITGa6 (A380T) and ITGb4 (R1281W) genetic variations in breast cancer susceptibility, in a female population from the northeast region of Argentina (Misiones). We performed a case-control study of 85 breast cancer patients and 113 cancer-free controls. Genotyping was performed by RFLP-PCR. For ITGa6 (A380T) single nucleotide polymorphism, a high frequency of heterozygousgenotype GA in cases compared to controls was observed, achieving values of 48% and 49%, respectively. No association between the A380T SNP and breast cancer development was found (Odds Ratio = 0.92; 95% Confidence Interval = 0.52?1.63; p = 0.884). In conclusion, we did not find evidence of an association between A380T (ITGa6) and the risk of developing breast cancer.The results represent the first report of these genetic variations in breast cancer; therefore, they are an important contribution to the literature.