INVESTIGADORES
ZAPATA Pedro Dario
artículos
Título:
Fosfotirosina fosfatasa SHP-1, somatostatina y cáncer de próstata
Autor/es:
ZAPATA PD, COLAS B, LÓPEZ-RUIZ P, ROPERO RM, MARTIN RM, RODRIGUEZ FJ, GONZÁLEZ FJ, LÓPEZ JI, ANGULO JC.
Revista:
ACTAS UROLOGICAS ESPANOLAS
Editorial:
Sociedad Española de Urología
Referencias:
Lugar: Madrid; Año: 2004 p. 269 - 285
ISSN:
0210-4806
Resumen:
We review the mechanisms involved in prostatic growth based on androgens and product of neuroendocrine secretion, with special reference to the role of somatostatin (SS) in the inhibition of neoplastic growth. Our contributions in the field confirm the antiproliferative effect of SS on the prostate is mediated by phosphotyrosine phosphatase SHP-1, that is present in human prostate. This enzyme plays a role in the control of prostatic cell proliferation and in the progression of prostate cancer. Besides, we consider its presence may determine the therapeutic potential of SS in the control of prostate cancer.
