INVESTIGADORES
ZAPATA Pedro Dario
artículos
Título:
Association Between Methylation of SHP-1 Isoform I and SSTR2A Promoter Regions with Breast and Prostate Carcinoma Development
Autor/es:
TISCORNIA, MARÍA MERCEDES; GONZALEZ, HEIDI; LORENZATI, MARÍA ANGÉLICA; ZAPATA, PEDRO DARÍO
Revista:
CANCER INVESTIGATION
Editorial:
TAYLOR & FRANCIS INC
Referencias:
Año: 2015 p. 1 - 9
ISSN:
0735-7907
Resumen:
Methylation pattern is presented here for first time as a potential molecular marker of changes on SSTR2A and SHP-1(I) gene promoter related to breast and prostate carcinoma. Our results have shown low concordances with SSTR2A and methylated state in prostate cancer andmoderate relationship with unmethylated CpG-27 in breast cancer.We found significant concordances for both cancers and SHP-1(I) unmethylation, and increased HER2 expression and SSTR2A methylation in breast cancer. Moreover, we found a correlation between methylation patterns of two genes in normal breast tissue. These datamight assist to select subgroups of patients for the administration of alternative therapies.
