INTERACTION OF XANTHONES AND DERIVATIVES WITH DPPC MEMBRANES

CEJAS, J.; ROSA, A.S ; GERBINO, D.; APPIGNANESI, G.; DISALVO, E.A.; FRÍAS, M.A.

Santiago del Estero

Congreso; Sociedad Argentina de Biofísica XLIV Reunión Anual 2015; 2015

Sociedad Argentina de Biofisica (SAB)

Xanthones are one of the biggest classes of compounds in natural product chemistry. A number of xanthones have been isolated from natural sources of higher plants, fungi, ferns, and lichens. They have gradually risen to great importance because of their medicinal properties. Xanthones are sometimes found as the parent polyhydroxylated compounds but most are mono-or polymethyl ethers or are found as glycosides. Many xanthones have been found to exhibit pronounced biological activities, for example anti-tumour effects. In the present work, the interactions between Xanthones and lipid bilayers as well as biological membranes and their components are studied. Xanthones can interact with lipid components of biological membranes and alter their properties. The polar region of the lipid bilayer limits the interactions. Moreover, the depth of membrane penetration by this type of compounds depends on their structure. According to the results obtained by Langmuir monolayers the presence of xanthones in DPPC produces a similar effect compared with the cholesterol. These interactions are also studied by FTIR-ATR spectroscopy.