PERSONAL DE APOYO
POSIK Diego Manuel
artículos
Título:
Molecular characterization of attenuated Junin virus strains
Autor/es:
ALBARIÑO CG, GHIRINGHELLI PD, POSIK DM, LOZANO ME, AMBROSIO AM, SANCHEZ A, ROMANOWSKI V.
Revista:
JOURNAL OF GENERAL VIROLOGY
Referencias:
Año: 1998 vol. 78 p. 1605 - 1610
ISSN:
0022-1317
Resumen:
The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper we report the nucleotide sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and other closely and distantly related arenaviruses was also examined. Comparisons of the nucleotide and amino acid sequences of N and GPC genes from Candid #1 and its progenitor strains revealed some changes that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype.
