Impact of Hyperglycaemia and the Therapeutic Action of Metformin on the Length of the Telomers

ANDREA LILIANA MILLÁN; MARÍA CONSTANZA PAUTASSO; LÓPEZ ARIEL PABLO; DE DIOS ALEJANDRO; ANDREA ELENA IGLESIAS MOLLI; MARÍA AMELIA LINARI; FRECHTEL GUSTAVO DANIEL; CERRONE GLORIA EDITH

Congreso; XXII Congreso Argentino & 1º Congreso virtual de Diabetes; 2020

Sociedad Argentina de Diabetes (SAD)

SummaryObjectives: Hyperglycemia is one of the most important factors that determine the production of oxidative stress and inflammation, processes that can accelerate telomere shortening. The objectives were to analyse the absolute telomere length (aTL) in individuals with altered fasting glucose levels (AFG) compared to individuals with normal glucose levels (NFG). To study from a prospective controlled study, the variation in aTL in patients with decompensated type 2 diabetes (T2D) before and after treatment.Materials and Methods: A population of 246 individuals of both genders was studied, which were divided into a group of individuals with blood glucose levels