Analysis of Telomere Length in Women with Polycystic Ovary Syndrome

MILLÁN ANDREA LILIANA; VELAZQUEZ MARIELA EDITH; ABRUZZESSE GISSELLE; COCUCCI SILVINA; IGLESIAS MOLLI ANDREA ELENA; GRAFFIGNA MABEL NORA; FRECHTEL GUSTAVO DANIEL; MOTTA ALICIA; CERRONE GLORIA EDITH

Encuentro; Joint Meeting SAIC SAI SAFIS LXIII Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXVI Annual Meeting of Sociedad Argentina de Inmunología (SAI) and Annual Meeting of Sociedad Argentina de Fisiología (SAFIS); 2018

Sociedad Argentina de Investigación Clínica (SAIC), Sociedad Argentina de Inmunología (SAI) y Sociedad Argentina de Fisiología (SAFIS), con la participación de la Sociedad Argentina de Virología (SAV) y Asociación Argentina de Nanomedicinas (NANOMED-ar)

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women in their reproductive age. We aimed to determine the absolute LT (LTa) in women with PCOS in comparison with healthy controls and their association with metabolic variables and the presence of hyperandrogenism.We analyzed 86 control women and 130 PCOS patients (16-46 years of age). Measurements of biochemical, clinical, anthropometric and hormonal variables were made. Biochemical hyperandrogenism (HA) presence was determined (total testosterone levels higher than 0.9ng/mL). LTa determination was performed on genomic DNA from peripheral blood leukocytes by Real Time PCR absolute quantitative method. The relationship kpb of telomeric sequences and copies of the single copy gene RPLPO (radio T/S) was determined. Statistical analysis were carried out by one-way ANOVA and linear regression. PCOS patients have a higher weight, body mass index (BMI), greater waist circumference (WC), higher levels of triglycerides (TG), and fasting plasma glucose as compared to controls. An inverse relationship was observed between LTa and age (p=0.004). PCOS patients presented increased LTa as compared to controls (p=0.001, adjusted for age: p=0.005). Moreover, we found higher levels of LTa in PCOS-HA women as compared to PCOS-NHA and Controls (p=0.004). In PCOS patients, we found an association between higher LTa and lower BMI (p=0.040), lower WC (p = 0.004), lower TG levels (p = 0.049), lower DPB (p=0.001) and higher c-HDL (p=0.004). In conclusion, LTa presents an inverse relationship with age in the studied population. The significantly increased LTa in PCOS patients (as compared to controls) could be a consequence of the presence of different metabolic, but mainly, hormonal components. A lower LTa was associated with presence of metabolic syndrome components, while biochemical HA was associated with higher LTa. Our results contribute to knowledge about the role of LT in the pathophysiology of PCOS.