Protective effects of Yerba Mate (IIex paraguariensis) on prostate cancer development

SANTIANO, FLAVIA E.; FERNÁNDEZ, MARÍA DE LOS ÁNGELES; ESPINO, MAGDALENA; ZYLA, LEILA E; REY, LARA; GÓMEZ, SILVINA E; BRUNA, FLAVIA; PISTONE-CREYDT, VIRGINIA; PIETROBON, ELISA O; PÉREZ ELIZALDE, RAFAEL; SILVA, MARÍA F; CARÓN, RUBÉN W.; LÓPEZ-FONTANA, CONSTANZA M

NUTRITION

ELSEVIER SCIENCE INC

Año: 2022

0899-9007

Prostate cancer (PCa) is the most common adenocarcinoma in men over 50 years old. It has a long latency period, which provides time for preventive strategies like incorporating healthy eating habits. Yerba mate (YM) intake has been associated with numerous health benefits. Since YM is one of the most popular infusions in Argentina, we aimed to study the influence of YM on PCa development. On one hand, we carried out an in vivo model of PCa through subcutaneous inoculation of TRAMP-C1 cells in C57BL/6 mice. Subsequently, the animals were divided into two groups: MATE (25 mg/ml of YM in drinking water, n=15), and CONTROL (only drinking water, n=15).On the other hand, we developed an in vitro model to study the direct effects of YM on three human PCa cell lines: LNCaP, PC3, and DU145. Our in vivo model showed that YM intake slightly reduced body weight, increased the latency of tumor appearance (p