Open to Closed-Loop Transition Schemes for in vivo Glucose Control

EMILIA FUSHIMI; NICOLÁS ROSALES; HERNÁN DE BATTISTA; FABRICIO GARELLI

Capital Federal

Congreso; Congreso Argentino de Control Automático; 2016

Continuous Subcutaneous Insulin Infusion (CSII) treatments for people with type 1 diabetes can combine the use of a smart insulin pump with a Continuous Glucose Monitor (CGM) and a control algorithm to improve the regulation of the insulin delivery during the postprandial period. New control algorithms need to be tested in clinical trials. In this paper, a safety layer called the SAFE loop (Revert et al., 2013) is reformulated to be employed during clinical trials in two different ways: the Time Enable mode, which gives a criterion for the transition between open and closed-loop therapy in hybrid configurations, and the Amplitude Enable mode, which diminishes the risk of an hypoglycemic event when testing fully closed-loop algorithms.