Mammary gland development in male rats perinatally exposed to propiconazole, glyphosate, or their mixture

GOMEZ, AYELEN L.; ALTAMIRANO, GABRIELA A.; ALCARAZ, MIRTA R.; MONTEMURRO, MILAGROS; SCHIERANO-MAROTTI, GONZALO; ODDI, SOFIA L.; CULZONI, MARÍA J.; MUÑOZ-DE-TORO, MÓNICA; BOSQUIAZZO, VERÓNICA L.; KASS, LAURA

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

ELSEVIER SCIENCE BV

Año: 2023 vol. 101

1382-6689

This study aimed to assess whether perinatal exposure to propiconazole (PRO),glyphosate (GLY) or their mixture (PROGLY) alters key endocrine pathways and thedevelopment of the male rat mammary gland. To this end, pregnant rats were orallyexposed to vehicle, PRO, GLY, or a mixture of PRO and GLY from gestation day 9until weaning. Male offspring were euthanized on postnatal day (PND) 21 and PND60.On PND21, GLY-exposed rats showed reduced mammary epithelial cell proliferation,whereas PRO-exposed ones showed increased ductal p-Erk1/2 expression withouthistomorphological alterations. On PND60, GLY-exposed rats showed reducedmammary gland area and estrogen receptor alpha expression and increased aromataseexpression, whereas PRO-exposed ones showed enhanced lobuloalveolar developmentand increased lobular hyperplasia. However, PROGLY did not modify any of theendpoints evaluated. In summary, PRO and GLY modified the expression of keymolecules and the development of the male mammary gland individually but nottogether.