Availability of a rich source of sodium during the perinatal period programs the cardiovascular response after Nitroprusside infusion in adult offspring

PORCARI C; MACAGNO, A; CAEIRO, X; VIVAS, L; GODINO, A.

Buenos Aires

Congreso; SAFIS. REUNION ANUAL 2021: Descubriendo los engranajes fisiológicos desde la evolución a la traslación; 2021

SAFIS

Osmoregulatory mechanisms may be vulnerable to environmental electrolyte and / or endocrine changes during the perinatal period, differentially programming developing-offspring and affecting them even in adulthood. Our previous results have shown that voluntary sodium intake during pregnancy and lactation induces a long-term effect on the adult offspring osmoregulatory response to osmotic challenges. The aim of this study was to evaluate whether the free access to hypertonic NaCl solution (HipNaCl) during the perinatal period can induce a differential programming of the cardiovascular response induced by a vasodilator agent ?sodium nitroprusside? in adult offspring. With this purpose, we studied Wistar rats, which manipulation (M) period covered dams from 1 week before conception until offspring turned 1-month old. The experimental group (M-NaCl) had free access to HipNaCl (0.45M NaCl), food and water; and control group (M-Ctrol) had free access to food and water only. We evaluated in male and female offspring (2-month-old) the changes(Δ), in the Mean Arterial Pressure (MAP), the Heart Rate (HR), the Pulse Pressure, the Diastolic and Systolic Arterial Pressure (DAP,SAP) induced by Sodium Nitroprusside iv infusion (1mg/ml). The data were expressed as M±SE; n = 10.The repeated measures ANOVA indicated that in male and female Nitroprusside decreased the ΔMAP (male: Ftreat=36.79; p