DAM EARLY FREE ACCESS TO HYPERTONIC NACL SOLUTION INDUCES A LONG-TERM EFFECT ON BLOOD PRESSURE RESPONSE OF ADULT OFFSPRING

PORCARI, CINTIA; MACAGNO, AGUSTINA; CAEIRO, XIMENA; VIVAS, LAURA; GODINO, ANDREA

Congreso; REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2020; 2020

SAIC SAFIS SAI

Osmoregulatory mechanisms can be vulnerable to electrolyte and/or endocrine environmental changes during the perinatal period, affecting their responses even in adulthood when the stimulus has disappeared. The aim of this study was to evaluate whether the availability of hypertonic sodium chloride solution during the perinatal period may induce a differential programming on cardiovascular responses of adult offspring after an osmotic challenge.We studied Wistar rats, with a perinatal manipulation (M) that covered dams from 1 week before conception until the 28 postnatal days (PN) of the offspring. The experimental groups were: -M-NaCl: Free access to 0.45M NaCl solution, food and water); and -M-Ctrol: Free access to food and water. We evaluated in male and female adult offspring (60PN) the changes (Δ), in the mean arterial pressure (MAP), the heart rate (HR), and diastolic-systolic arterial pressure (DAP and SAP) induced by 2M NaCl infusion.The repeated measures ANOVA indicated that both, M-Ctrol and M-NaCl males increased the MAP (F7.133=36.786; p