NEUTROPHILS FROM CHILDREN WITH ACUTE COVID-19 EXHIBIT AN INFLAMMATORY SIGNATURE WITH A DISTINCT EXPRESSION OF HIGH AFFINITY RECEPTOR FOR IgG

SEERY, VANESA; RAIDEN, SILVINA; ALGIERI, SILVIA; FILIPPO, DANIELA; DE CARLI, NORBERTO; CAIROLI, HÉCTOR; CHIOLO, MARÍA J.; DI LALLA, SANDRA; GRISOLÍA, NICOLÁS A.; GREGORIO, GABRIELA; LATTNER, JORGE; COLL, PATRICIA; ROLÓN, MARÍA J.; MELUCCI, CLAUDIA; SANANEZ, INÉS; HOLGADO, MARÍA PÍA; FERRERO, FERNANDO; GEFFNER, JORGE; ARRUVITO, LOURDES

Congreso; Reunión anual de sociedades de Biociencias 2020; 2020

BACKGROUND: Children can be infected by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), being most pediatric cases mild but the reason underlying are still unknown. This study addressed the immunopathological characteristics of neutrophils from acute COVID-19 infected children. METHODS: Sixty acute COVID-19 mildly infected children (1-14 years-old) and 9 healthy infants were studied. A multiparametric flow cytometry from neutrophils was performed in whole blood. Levels of IL-1β in supernatant culture from purified neutrophils and serum anti SARS-CoV-2 IgG were quantified by ELISA. RESULTS: A low expression of CD11b (p