Dietary iodine deficiency during pregnancy in cattle

COLQUE-CARO LUIS A ; ACUÑA FRANCISCO; AGUIRRE LAURA S; AVELLANEDA-CÁCERES AGUSTÍN; BARBEITO CLAUDIO G; SIGNORINI MARCELO; MOORE DADIN P; MICHELOUD JUAN F

JOURNAL OF COMPARATIVE PATHOLOGY

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2023

0021-9975

There are few studies that classify and characterize the morphometric and immunohistochemical features of goitre in bovine thyroid glands (TGs). We investigated 49 bovine TGs [fetuses (9), stillbirths (18) and neonates (12) born to dams with low T4 hormone levels and no iodine supplementation, and 10 [fetuses (3), stillbirths (3) and neonates (4)] born to dams with normal T4 levels and supplemented with iodine. Body weight (BW), TG weight (TGW), TGW:BW ratio and histological lesions were determined. The TGs were classified histopathologically as normal gland (G0), or mild (G1), moderate (G2) or severe goitre (G3). Various morphological and morphometric parameters were calculated from microscopic images using image analysis software. Immunohistochemistry was performed to detect proliferating cell nuclear antigen (PCNA). There were significant differences in TGW:BW ratio among groups (P