Massive depletion of BLV proviral clones located in genomic trenscriptionally active sites during Primary infection

GUILLET NICOLAS; GERONIMO GUTIERREZ; ALIX DE BROGNIEZ; SABRINA M. RODRIGUEZ; RENOTTE NATHALIE; ALVAREZ IRENE; VAGNONI LUCAS; KARINA TRONO; WILLEMS LUC

Montrial

Conferencia; 16th Conference on Human retrovirology: HTLV and related viruses; 2013

Nicolas A Gillet, Geronimo Gutierrez, Alix de Brogniez, Sabina M. Rodriguez, Nathalie Renotte, Irene Alvarez, Lucas Vagnoni, Karina Trono Luc Willems.Massive depletion of BLV proviral clones located in genomic trenscriptionally active sites during Primary infection.Prion diseases are fatal neurodegenerative disorders in man and animal associated with the conformational conversion of a cellular prion protein (PrPc) into a pathological isoform (PrPSc). Prionoses can be infective and transmissible mainly by contaminated food ingestion. In Argentina, Lama Glama meat is commonly used as human food. The National Surveillance Program monitors South American Camelid brain samples for the presence of transmissible spongiform encephalopathy (TSE). Interspecies infectivity of TSEs varies greatly, with PrP sequence homology between two species probably playing a role in the species barrier phenomenon; however, this feature alone cannot always be used to predict whether the barrier between two species is high or low. Nevertheless, an early genotype analysis of PrP genes from species not yet reported as susceptible might be useful to predict potential epidemiological problems.