INCREASED LEVELS OF CIRCULATING LPS IN PATIENTS WITH ADVANCED PULMONARY TUBERCULOSIS.

GALUCCI GEORGINA; SANTUCCI, NATALIA; DIAZ ARIANA; BONGIOVANNI, BETTINA; DIEGO BERTOLA2,3; GARDÉÑEZ WALTER; BAY, MARÍA LUISA; BOTTASSO, OSCAR; DATTILIO, LUCIANO; COLABORACIÓN TÉCNICA: MARISA E. DERIO

Ciudad Autonoma de Buenos Aires

Congreso; Reunión Anual de Sociedades de Biociencias; 2020

Sociedad Argentina de Inmunologia

Tuberculosis (TB) continues to be a global health problem. Our studies indicate that in those individuals where the process evolves to a larger pulmonary involvement, the regulatory action of the endocrine system is likely to promote a potentially unfavorable environment, either for the mounting of protective immunity, or the proper control of the inflammatory mechanisms accompanying such protracted course. Chronic infectious diseases, as is the case of TB, and its persistent pro-inflammatory response may lead to changes in the mucosal barriers affecting its integrity and hence the translocation of bacteria that line the gastrointestinal tract. As such, individuals with chronic diseases may have slightly increased levels of circulating Lipopolysaccharides (LPS). Given this, we set out to quantify plasma LPS levels (chromogenic assay) in TB patients (n=39) and healthy volunteers (Co, n=38) in addition to analyzing the possible correlations between LPS levels and other inflammatory mediators such as C-reactive protein (CRP, turbitest), interleukin-6 (IL-6, ELISA) and Interferon-gamma (IFNγ, ELISA) as well as the Erythrocyte Sedimentation Rate (ESR). Compared to Co, plasma LPS levels were found increased in TB patients (p=0.009), as did levels of inflammatory mediators (CRP, p