Studies on the contribution of PPAR Gamma to tuberculosis physiopathology

DÍAZ, ARIANA; D?ATTILIO, LUCIANO; PENAS, FEDERICO; BONGIOVANNI, BETTINA; MASSA, ESTEFANÍA; CEVEY, AGATA; SANTUCCI, NATALIA; BOTTASSO, OSCAR; GOREN, NORA; BAY, MARÍA LUISA; COLABORACIÓN TÉCNICA: MARISA E. DERIO

Frontiers in Cellular and Infection Microbiology

Universidad de Buenos Aires, Argentina

Año: 2023 vol. 13

Tuberculosis (TB) is a major health problem characterized by animmuno-endocrine imbalance: elevated plasma levels of cortisol and pro- andanti-in fl ammatory mediators, as well as reduced levels ofdehydroepiandrosterone. The etiological agent, Mycobacterium tuberculosis(Mtb), is captured by pulmonary macrophages (Mf), whose activation isnecessary to cope with the control of Mtb, however, excessive activation ofthe inflammatory response also leads to tissue damage. Glucocorticoids (GC) arecritical elements to counteract the immunoinflammatory reaction, andperoxisome proliferator-activated receptors (PPARs) are also involved in thisregard. The primary forms of these receptors are PPARϒ, PPARa, and PPARb/d,the former being the most involved in anti-inflammatory responses. In this work,we seek to gain some insight into the contribution of PPARϒ in immunoendocrine-metabolic interactions by focusing on clinical studies in pulmonaryTB patients and in vitro experiments on a Mf cell line.