Priming Against Pathogens Mediated by the Chromatin Remodeler MOM1

MIRANDA DE LA TORRE JO; PEPPINO MARGUTTI M; MARIA ELENA ALVAREZ; CECCHINI, NICOLAS M (CORRESPONDING AUTHOR)

Congreso; 31st INTERNATIONAL CONFERENCE ON ARABIDOPSIS RESEARCH; 2021

PRIMING AGAINST PATHOGENS: THE ROLE OF THE CHROMATIN REMODELER MOM1Miranda de la Torre JO, Peppino Margutti M, Alvarez ME, Cecchini NM CIQUIBIC-CONICET, Department of Biological Chemistry Ranwel Caputto-Faculty of Chemical Sciences?UNC. E-mail: ncecchini@unc.edu.ar Plants systemic resistance programs against pathogens are usually associated to an immunological "memory" or priming. Despite not showing constitutive defenses, the primed state allows for a more efficient response to recurrent infections. Priming may involve epigenetic modifications for a predisposition to a rapid/strong transcriptional activation of defense genes. The chromatin remodeler "Morpheus Molecule" (MOM1) was recently proposed as a priming factor associated with the activation of defenses during aging. Here, we analyzed the relation between MOM1 and the induction/establishment of priming in Arabidopsis. We found that, independently of the development stage, under optimal conditions of growth and sterility the mom1 mutant plants show increased levels of key immune receptors without the constitutive induction of resistance-associated marker genes. In addition, mom1 is more sensible to the priming inducers azelaic acid (AZA) and aminobutyric acid (BABA). Consistently, transgenic plants that express a minimal but functional version of MOM1 (mini-MOM1) show a reduced response to these inductors. Moreover, treatments with AZA or BABA induced low MOM1 transcript levels in wild-type plants. Together, our results suggest that the chromatin remodeler MOM1 act as a negative regulator of the priming against pathogens in Arabidopsis.