Distribution of bovine alpha-herpesviruses and expression of toll-like receptors in the respiratory system of experimentally infected calves

MARIN M.S.; QUINTANA S.; LEUNDA M.R. ; ODEÓN A.C. ; PÉREZ S.E.

RESEARCH IN VETERINARY SCIENCE

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2016 vol. 105 p. 53 - 55

0034-5288

This study provides an initial analysis of the toll-like receptors (TLRs) that might be implicated in alphaherpesvirus infection of the bovine respiratory system. A significant variation in the expression of TLR3 andTLRs 7?9 during bovine herpesvirus type 1 (BoHV-1) and 5 (BoHV-5) acute infections and particularly an upregulation during viral reactivation in respiratory tissues has been demonstrated. Furthermore, viral distributionin the respiratory tract of BoHV-1- and BoHV-5-infected calves at different stages of the infectious cycle was analysed. The wide distribution of BoHV DNA in the respiratory tract during acute infectionwas restricted duringlatent infection and the subsequent reactivation of BoHV-1 and BoHV-5. Overall, the findings presented here contribute to the knowledge on the replication and dissemination of bovine alpha-herpesviruses. Furthermore, some of the immune factors triggered in the host that determine the different outcomes of infection by two closely related pathogens of cattle have been elucidated.