Diabetes Primary Prevention Program: New Insights From Data Analysis of Recruitment Period

GAGLIARDINO, JUAN J.; ELGART, JORGE F.; ETCHEGOYEN, GRACIELA; FANTUZZI, GABRIEL; R¨¦, MAT¨ªAS; RICART, JUAN P.; GARC¨ªA, SILVIA; GIAMPIERI, CECILIA; GONZ¨¢LEZ, LORENA; SU¨¢REZ-CRIVARO, FLORENCIA; KRONSBEIN, PETER; ANGELINI, JULIETA M.; MART¨ªNEZ, CAMILO; MART¨ªNEZ, JORGE; RICART, ALBERTO; SPINEDI, EDUARDO

DIABETES/METABOLISM RESEARCH AND REVIEWS.

JOHN WILEY & SONS LTD

Año: 2018 vol. 34

1520-7552

OBJECTIVES: Primary Prevention of Diabetes Program in Buenos Aires Province (PPDBA) evaluates the effectiveness of adopting healthy lifestyle to prevent type 2 diabetes (T2D) in people at high risk of developing it. We aimed to present preliminary data analysis of FINDRISC and laboratory measurements taken during recruitment of people for the PPDBA in the cities of La Plata, Berisso and Ensenada, Argentina. METHODS: People were recruited through: Population approach (house to house survey by FINDRISC in randomized areas) and opportunistic approach (FINDRISC completed by participants during consultations for non-related pre-diabetes/diabetes symptoms in public and private primary care centers of cities involved). In people with FINDRISC score ¡Ý13 points we evaluated blood concentrations of HbA1c, creatinine, lipids and an oral glucose tolerance test (OGTT). RESULTS: 3415 individuals completed the FINDRISC populational survey and 344 the opportunistic survey; 43% of the two groups scored over 13 points; 2.8 and 75.4% of them, respectively, took the prescribed OGTT. 53.7% of the OGTT showed normal values and 5.2% unknown T2D. The remaining cases showed 69.5% impaired fasting glucose (IFG), 13.6% impaired glucose tolerance (IGT) and 16.9% both impairements. HbA1c values showed significant differences compared to normal glucose tolerance (NGT; 4.96¡À0.43%), pre-diabetes (5.28¡À0.51%) and T2D (5.60¡À0.51%). Participants with pre-diabetes and T2D showed a predominant increase in LDL-cholesterol values. In pre-diabetes, > 50% showed insulin resistance (IR). CONCLUSIONS: People with pre-diabetes/T2D had dyslipidemia associated with IR which promotes the development of T2D and cardiovascular disease. Thus, it merits its appropriate treatment.