BECAS
RODRÍGUEZ VARELA Maria Soledad
artículos
Título:
Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of <2 (GGGGCCG) and 10 repeats
Autor/es:
NIEVAS, MICAELA; ROMORINI, LEONARDO; ISAJA, LUCIANA; CLAS, GIULIA S; RODRÍGUEZ-VARELA, MARÍA SOLEDAD; MUCCI, SOFÍA; ITZCOVICH, TATIANA; DE AMBROSI, BRUNO; SCASSA, MARÍA ELIDA; SEVLEVER, GUSTAVO EMILIO; SURACE, EZEQUIEL IGNACIO; MARAZITA, MARIELA
Revista:
Stem Cell Research
Editorial:
Elsevier B.V.
Referencias:
Lugar: Amsterdam; Año: 2023 vol. 69
Resumen:
Human induced pluripotent stem cell (hiPSC) line INEUi001-A was reprogrammed from peripheral blood mononuclear cells (PBMC) using the lentiviral-hSTEMCCA-loxP vector. PBMCs were obtained from a 75- year-old female ALS/FTD disease patient carrying a heterozygous deletion within the C9ORF72 hexanucleotide repeat region resulting in a GGGGCCG sequence (∼1.16 repeats). C9ORF72 genotype was maintained and stemness and pluripotency confirmed in INEUi001-A hiPSC line.
