POSSIBLE SENESCENCE ASSOCIATED CHANGE IN THE PREDOMINANT a-Na+/K+ ATP-ase ISOFORM IN THE RENAL CORTEX OF THE RAT

POTILINSKI M.; MORETTA R.; CASAL L.; GARCÍA-GRAS E.; AMORENA C.

MEDICINA (BUENOS AIRES)

MEDICINA (BUENOS AIRES)

Lugar: Buenos Aires; Año: 2016 vol. 76 p. 204 - 207

0025-7680

With aging the kidney exhibits progressive deterioration, with a decrease in renal function. Mostof the filtered Na+ is actively reabsorbed in the proximal tubules through different transporters locatedin apical membrane. This process is possible because basolateral Na+/K+-ATP-ase generates electrochemicalconditions necessary for energetically favorable Na+ transport. The α-subunit is the catalytic domain of Na+/K+-ATP-ase. There are three isoforms of the α/subunit present in rat kidney. The present study was undertaken toexamine the expression pattern of rat α-Na+/K+-ATP-ase during senescence. We tested the impact of aging onmRNA expression of α-Na+/K+-ATP-ase in cortex and medulla of aged Wistar rats. We observed a significantexpression decrease in mRNA levels and a possible change of isoform in the cortex of aged animals. Theseexpression changes observed for α subunit could be contributing to affect the renal function in conditions of waterand salt stress.