Synthesis and characterization of new acridone glucisides

MIRTA L. FASCIO; NORMA B. D´ACCORSO; MAITE L. DOCAMPO; ROLANDO F. PELLÓN

Palermo - Italia

Congreso; 20th International Congress of Heterocyclic Chemistry; 2005

In the last years some acridone derivatives have been reported as anti-multidrug resistant (1), anti-cancer activities (2) and telomerase inhibitors (3) between others. Due to the important properties these sorts of compounds present and their potential applicability, we decide to synthesize new N-substituted acridones. We have already reported the synthesis of N-allyl and N-propardienylacridones using phase-transfer catalysis (4). Following the synthetic pathway, we apply 1,3-dipolar cycloaddition techniques to obtain some novel acridone glucosides 3 from the corresponding N-allyl derivatives 2. In this work, we describe the characterization of these new compounds