BECAS
ROBERTI Sabrina Lorena
congresos y reuniones científicas
Título:
THE MATERNAL TREATMENT WITH CHIA OIL IN DIABETIC RATS (F0) REDUCES THE OVERACTIVATION OF MTOR PATHWAYS IN THE PLACENTA FROM THEIR OFFSPRING (F1) THAT DEVELOPS GESTATIONAL DIABETES MELLITUS
Autor/es:
DAIANA FORNES; DALMIRO GOMEZ RIBOT; SABRINA LORENA ROBERTI; ALICIA JAWERBAUM; EVANGELINA CAPOBIANCO
Lugar:
Mar del Plata
Reunión:
Congreso; LXIII Reunión Anual de la Sociedad Argentina de Investigación Clinica; 2018
Resumen:
e offspring (F1) from mild diabetic rats (F0) develops gestationalGLDEHWHV PHOOLWXV *'0 D UDW PRGHO ZLWK LQFUHDVHG IHWDO JURZWKDVVRFLDWHG ZLWK WKH RYHUDFWLYDWLRQ RI SODFHQWDO PHFKDQLVWLF WDUJHWRIUDSDP\FLQP725VLJQDOLQJ0DWHUQDOGLHWVVXSSOHPHQWHGZLWKSRO\XQVDWXUDWHGIDWW\ DFLGV 38)$V KDYH EHQHÀFLDOPHWDEROLF HIfects in the placenta from pregestational diabetic rats.$,0WRVWXG\WKHHIIHFWRIDPDWHUQDOWUHDWPHQWZLWKFKLDRLOLQGLDEHWLFUDWV)RQWKHIHWDOZHLJKWDQGSODFHQWDOP725SDWKZD\VLQtheir offspring (F1) that develops GDM.0(7+2'6FRQWURODQGGLDEHWLFUDWV)ZHUHIHGZLWKDVWDQGDUGGLHWRUDGLHWVXSSOHPHQWHGZLWKFKLDRLOULFKLQQ38)$V&+JURXSGXULQJJHVWDWLRQ7KHIHPDOHRIIVSULQJ)ZDVPDWHGZLWKhealthy males. Metabolic parameters and the mTOR signaling pathZD\VE\:HVWHUQEORWZHUHHYDOXDWHGLQWKHSODFHQWDIURPFRQWUROand GDM rats on day 21 of pregnancy.RESULTS: The development of GDM (fasting glycemia values
