BECAS
INGARAMO MarÍa Clara
artículos
Título:
Fat Body p53 Regulates Systemic Insulin Signaling and Autophagy under Nutrient Stress via Drosophila Upd2 Repression
Autor/es:
INGARAMO, MARÍA CLARA; SÁNCHEZ, JUAN ANDRÉS; PERRIMON, NORBERT; DEKANTY, ANDRÉS
Revista:
Cell Reports
Editorial:
Elsevier B.V.
Referencias:
Año: 2020 vol. 33
Resumen:
Ingaramo et al. report an essential role for adipose p53 in sensing nutrient stress, maintaining metabolic homeostasis, and extending organismal survival in Drosophila. AMPK-dependent Dmp53 activation under nutrient stress modulates Dilp2 circulating levels, systemic insulin/TOR signaling, and autophagy induction by repressing Leptin/Upd2 expression in adipose cells.