Fat Body p53 Regulates Systemic Insulin Signaling and Autophagy under Nutrient Stress via Drosophila Upd2 Repression

INGARAMO, MARÍA CLARA; SÁNCHEZ, JUAN ANDRÉS; PERRIMON, NORBERT; DEKANTY, ANDRÉS

Cell Reports

Elsevier B.V.

Año: 2020 vol. 33

Ingaramo et al. report an essential role for adipose p53 in sensing nutrient stress, maintaining metabolic homeostasis, and extending organismal survival in Drosophila. AMPK-dependent Dmp53 activation under nutrient stress modulates Dilp2 circulating levels, systemic insulin/TOR signaling, and autophagy induction by repressing Leptin/Upd2 expression in adipose cells.