INVESTIGADORES
PESCE VIGLIETTI AyelÉn Ivana
congresos y reuniones científicas
Título:
Brucella abortus infection elicited hepatic stellate cells (HSC) fibrosis through inflammasome-dependent IL-1β production.
Autor/es:
PAULA CONSTANZA ARRIOLA BENITEZ; AYELÉN IVANA PESCE VIGLIETTI; DIEGO COMERCI; GUILLERMO HERNÁN GIAMBARTOLOMEI; MARÍA VICTORIA DELPINO
Lugar:
Mar del Plata
Reunión:
Congreso; LXI reunión anual de la sociedad argentina de investigación clínica (SAIC) LXIV Reunión anual de la sociedad argentina de inmunología (SAI) XLVIII Reunión anual de la sociedad argentina de farmacología experimental (SAFE).; 2016
Institución organizadora:
LXI reunión anual de la sociedad argentina de investigación clínica (SAIC) LXIV Reunión anual de la sociedad argentina de inmunología (SAI) XLVIII Reunión anual de la sociedad argentina de farmacología experimental (SAFE).
Resumen:
The liver is affected in human brucellosis. B. abortus (Ba) triggers on HSC a profibrotic response characterized by inhibition of MMP-9 with concomitant collagen deposition and TGF-β1 secretion in a way that involved a functional T4SS. Taking into account that it has been reported that inflammasome is necessary to induce a fibrotic phenotype in HSC, we hypothesized that Brucella infection might create a microenvironment that would promote inflammasome activation and a concomitant profibrogenic phenotype in HSC. Our results indicate that Ba infection induces IL-1β secretion (ELISA) by LX-2 cells by a mechanism dependent on a functional T4SS(p
